ABIO materials

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Biotech new materials

Production facility with the longest experience in Korea Demonstrating the longest domestic track record of safety /ABIO's unique patented technology

Plant Exosomes

  • ABIO's unique plant cell wall-breaking process is a technology that separates/purifies exosomes from plant cells without damaging them.
  • Plant exosomes comprise a phospholipid bilayer identical to human-derived exosomes
  • Contain enzymes, signaling molecules, proteins, DNA, RNA, lipids, and various metabolites similar to the plant cell's type, part, and origin.
  • Advantages of Plant Exosomes
    : Structurally very stable, able to easily pass through biological barriers due to the phospholipid bilayer.
      High biocompatibility, low toxicity, and deficient inflammatory response to immune reactions.
Plant Exosomes
ABIO's Plant Exosomes

Transcriptome analysis : Plant Exosome Transcriptome Analysis

  • ABIO has completed the transcriptome analysis of plant exosomes isolated and purified using the ExoTraction® technology.
  • A change in the expression of over 1,500 genes has been identified in plant exosomes compared to the control group.

DEG (Differentially Expressed Genes) Analysis/Changes in Gene Expression and KEGG Analysis

Compared to the control group, a change in the expression of over 1,500 genes has been confirmed in Centella Asiatica exosomes and other plant exosomes.

Heatmap of DEF list
MDS(Multidensional Scaling)
UP, DOWN regulated count

Plant Exosome miRNA Analysis

Analysis of miRNA in Centella Asiatica exosomes has shown regulation targeting genes related to melanin biosynthesis.

miRNA
Plant Exosome miRNA
No. Product Origin INCI Name Efficacy MOQ
1 (V)BioExo-Water(TeaTree) Tea tree Melaleuca Alternifolia (Tea Tree) Vesicles Anti-inflammatory 20KG, 100KG
2 (V)BioExo-Water(Cabbage) Cabbage Brassica Oleracea Capitata (Cabbage) Leaf Vesicles Anti-inflammatory 20KG, 100KG
3 (V)BioExo-Water(Rosemary) Rosemary Rosmarinus Officinalis (Rosemary) Vesicles Skin regeneration,
moisturization
20KG, 100KG
4 (V)BioExo-Water(Lotus) Lotus leaf Nelumbo Nucifera Leaf Vesicles Skin barrier,
moisturization
20KG, 100KG
5 (V)BioExo-Water(Fig) Fig Ficus Carica (Fig) Vesicles Hair loss improvement 20KG, 100KG
6 (V)BioExo-Water(Tomato) Tomato Solanum Lycopersicum (Tomato) Fruit Vesicles Brightening 20KG, 100KG
7 (V)BoiExo-Water(Grapefruit) Grapefruit Citrus Paradisi (Grapefruit) Fruit Vesicles Wrinkle improvement 20KG, 100KG
8 (V)BoiExo-Water(Camellia) Camellia Camellia Japonica Flower Vesicles Moisturization,
wrinkle improvement
20KG, 100KG
9 (V)BoiExo-Water(Spinach) Spinach Spinacia Oleracea (Spinach) Leaf Vesicles Hair loss improvement 20KG, 100KG
10 (V)BoiExo-Water(Garlic) Garlic Allium Sativum (Carlic) Bulb Vesicles Skin regeneration 20KG, 100KG
11 (V)BoiExo-Water(Green Tea) Green tea Camellia Sinensis Leaf Vesicles Anti-inflammatory,
moisturization
20KG, 100KG
12 (V)BoiExo-Water(Oat) Oat Avena Sativa (Oat) Kernel Vesicles Anti-inflammatory,
acne improvement
20KG, 100KG
13 (V)BoiExo-Water(Broccoli) Broccoli Brassica Oleracea Italica (Brocoli) Vesicles Hair loss improvement 20KG, 100KG
14 (V)BioExo-Water(Cica) Cica Centella Asiatica Leaf Vesicles Wrinkle improvement,
skin regeneration,
anti-inflammatory
20KG, 100KG
15 (V)BioExo-Water(Portula) Purslane
(portulaca)
Portulaca Oleracea Vesicles Moisturization,
anti-inflammatory
20KG, 100KG
16 (V)BioExo-Water(Heartleaf) Heartleaf
(Eoseongcho)
Houttuynia Cordata Vesicles Anti-inflammatory,
hair loss improvement
20KG, 100KG
17 (V)BioExo-Water(Skullcap) Skullcap Scutellaria Baicalensis Root Vesicles Hair loss improvement,
anti-inflammatory
20KG, 100KG
18 (V)BioExo-Water(Peony) Peony Paeonia Lactiflora Root Vesicles Wrinkle improvement 20KG, 100KG
19 (V)BioExo-Water(Makino) Makino Cnidium Officinale Root Vesicles Skin regeneration,
moisturization
20KG, 100KG
20 (V)BioExo-Water(Multiflora) Multiflora Polygonum Multiflorum Root Vesicles Hair loss improvement 20KG, 100KG
21 (V)BioExo-Water(Bracken) Bracken Pteridium Aquilinum Juice Vesicles Anti-inflammatory,
hair loss improvement
20KG, 100KG
22 Cellular Active IRISA EXO Iris Iris Germanica Root Extract Moisturization,
Wrinkle improvement
Exclusive
23 Exo-Perilla Perilla Leaf Perilla Ocymoides Leaf Vesicles Wrinkle improvement,
Skin regeneration,
Anti-inflammatory
Exclusive
24 Exo-Eucalyptus Eucalyptus Eucalyptus Globulus Leaf Vesicles Wrinkle improvement,
Skin regeneration,
Anti-inflammatory
Exclusive
25 (V)BioExo-Water(GT) Green tea Camellia Sinensis Leaf Vesicles Anti-inflammatory,
Skin barrier
Exclusive
(proprietary raw material)
26 (V)BioExo-Water(PG) Raw Ginseng Panax Ginseng Vesicles Anti-inflammatory,
Skin barrier
Exclusive
(proprietary raw material)

Plant PDRN

Plant PDRN (Plant Poly deoxyribonucleotide)

  • ABIO has developed a technology capable of isolating high-purity/high-efficiency low molecular weight plant PDRN using its unique technology, EssentractionTM.
  • Compared to existing salmon PDRN, plant PDRN developed by ABIO shows higher stability and efficacy.
  • Plant PDRN is a substance that promotes cell regeneration, selectively acts on the adenosine A2 receptor to promote cell proliferation and tissue regeneration at damaged sites, and exhibits anti-inflammatory effects.
PlandPDRN
Salmon vs. Plant

EssenTraction®

  • Efficiently eluting DNA inside the nucleus using a unique extraction buffer.
  • Technology for manufacturing low molecular PDRN through purifying DNA at high purity and then using cold plasma technique.
EssenTractionTM
Plant PDRN quantification

Plant Retinol

Plant-Derived Retinol

  • Development of Simultaneous Multiple Gene Expression Technology
  • Development of genetically modified poplar with overexpression of multiple retinol biosynthesis genes.
  • The beta-carotene in poplar is converted into retinol (Vitamin A) through human retinol biosynthesis genes, providing exceptional efficacy in improving wrinkles and increasing skin elasticity.

Development of poplar for mass production of active substances using simultaneous multiple gene expression system

Development of poplar for mass production of active substances using simultaneous multiple gene expression system
식물 레티놀 실험
특허 등록(등록번호 제 10-2585826호)